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| Generic drugs news |
22.10.2011
Generics in the United Kingdom - Performance of the Market Is Forecast To Decelerate, With an Anticipated CAGR Of 7.9% for the Five-Year Period 2010... [reading]
22.10.2011
The US Generics Market Had Total Revenue of $71.4 Billion in 2010, Representing A CAGR Of 8.2% between 2006 and 2010 [reading]
21.10.2011
Antares Pharma Granted New U.S. Patent Covering VIBEX? Injector Technology [reading]
21.10.2011
Drugs giants probed by EU anti-trust authority [Deutsche Welle] [reading]
20.10.2011
CMS` Transparency Push Could Revolutionize Drug Pricing [reading]
19.10.2011
Perrigo confirms filing for generic version of PATANASE nasal spray [reading]
19.10.2011
Pharmacists to Federal Medicaid Officials: Revamp Proposed Generic Drug Federal Upper Limits to Preserve Pharmacy Access for Patients [reading]
19.10.2011
Teva Pharmaceutical Industries Ltd. and Cephalon, Inc.; Analysis of Agreement Containing Consent Orders To Aid Public Comment [reading]
18.10.2011
Perrigo applies to FDA for generic nasal spray [reading]
18.10.2011
Watson confirms filing ANDA for generic version of Warner`s Atelvia [reading]
18.10.2011
Watson confirms filing ANDA with FDA for generic version of Noven`s Daytrana [reading]
17.10.2011
New NCPA Ads Feature Community Pharmacy Proposals to Reduce the Federal Deficit [reading]
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Price |
Per Item |
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Product information |
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Drug Name: Topamax (Topiramate) Drug Uses: Seizures may be classified as either partial if they involve only a small portion of the brain or generalized if they involve more of the brain. Topamax is used in combination with other anti-seizure drugs among adults and children aged 2-16 years with partial seizures or generalized tonic-clonic seizures (in which there is prolonged contraction of the muscles of the body that causes rigidity as well as jerking motions). Topamax sprinkle capsules are approved for treatment without other drugs in patients 10 years of age and older. Topamax also is used in patients two years of age and older with seizures associated with the Lennox-Gastaut Syndrome, a severe form of epilepsy which accounts for up to 10 percent of all cases of childhood epilepsy. Children with Lennox-Gastaut Syndrome experience delays in their development and up to dozens of different, mixed types of seizures a day. The most common types of seizures in this syndrome are tonic (stiffening of the body, with the eyes rolling upwards, dilation of the pupils and shallow, irregular breathing), atonic (brief loss of muscle tone and consciousness, causing abrupt falls), myoclonic (sudden muscle jerks), and absence (staring spells). How Taken: Most commonly, topamax is started in low doses, 25 or 50 mg per day, and then increased slowly, under a doctor's orders, by 25 to 50 mg per week until an effective daily dose is reached. This slow approach to treatment reduces side effects. In children, the starting dose is up to 25 mg (1 to 3 mg/kg/day), taken nightly for the first week. The dose is then increased at 1 or 2 week intervals by 1 to 3 mg/kg/day. Although the usual adult dose is 200 mg twice daily, some adult patients may begin to see a clinical response at 200 mg per day. Some patients need doses higher than 200 mg daily. In children, the usual dose is 2.5 to 4.5 mg/kg twice daily. Patients should maintain an adequate fluid intake in order to minimize the risk of kidney stones. Drug Class and Mechanism Topamax is an oral drug that is used to prevent the seizures of epilepsy. (It is an anti-epileptic or anti-seizure drug). It is used primarily among patients who are not controlled by other anti-epileptic drugs. About 1 in 4 Americans diagnosed with epilepsy has seizures that resist treatment with other anti-epileptic drugs. Topamax also prevents migraine headaches. Seizures are due to the abnormal activity ("firing") of nerves in the brain, and the abnormal activity spreads to smaller or larger portions of the brain. Although topamax's exact mechanism of action is unknown, scientific studies suggest that it may alter neurotransmitters within the brain. Neurotransmitters are chemicals that nerves manufacture and use to communicate with other nearby nerves. By altering the production or action of the neurotransmitters, topamax may suppress the abnormal activity of the nerves in the brain that cause the seizures or may prevent the abnormal activity from spreading to other nerves. Other studies suggest that topamax may suppress the nerves directly (i.e., not by altering neurotransmitters) and make them less likely to fire. Missed Dose If you miss a dose of this medicine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Storage Topamax tablets should be stored at room temperature, 59-86 degrees F (15-30 degrees C). Sprinkle capsules should be stored at or below 77 degrees F (25 degrees C). |
Warnings/Precautions |
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The following medications, when taken with topamax, increase the risk of kidney stones: acetazolamide (Diamox), dorzolamide (Trusopt), methazolamide (Neptazane), dichlorphenamide (Daranide). Carbamazepine (Tegretol) and phenytoin (Dilantin) markedly decrease the amount of topamax in the body by increasing its elimination from the body. As a result, topamax may lose effectiveness unless doses are increased. Topamax may decrease the amount of estrogen in the body in women taking oral contraceptives, possibly increasing the chances of unwanted pregnancy. Patients with seizure disorders taking anticonvulsant medications, including topamax, may develop nerve toxicity from a chemical, 4'-O-methylpyridoxine, found as a contaminant in some ginkgo preparations. Do not take this medicine if you have had an allergic reaction to it or are allergic to any ingredient in this product. Do not stop using this medicine without first checking with your doctor. Some conditions may become worse when the medicine is suddenly stopped. Keep all doctor and laboratory appointments while you are using this medicine. Laboratory and/or medical tests may be done, such as measuring bicarbonate levels in your blood, before you start taking this medicine and during therapy to monitor for side effects. Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are taking this medicine. This medicine will add to the effects of alcohol and other depressants. Ask your doctor or pharmacist if you have questions. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. This medicine may reduce sweating which could raise your body temperature, especially in children. The risk of this serious side effect is greater in hot weather and/or during vigorous exercise. Drink plenty of fluids and dress lightly while in hot climates, or when exercising. Check carefully for signs of decreased sweating. If this occurs, promptly seek cooler or air-conditioned shelter and/or stop exercising. Seek immediate medical attention if your body temperature is above normal, or if you have mental or mood changes, headache, or dizziness. Contact your doctor for more details. Before you begin taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. For women, taking this medicine while you are using birth control pills may decrease the effectiveness of your birth control pills. To prevent pregnancy, use an additional form of birth control while you are taking this medicine. Ask your doctor or pharmacist if you need more information. If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using this medicine during pregnancy. It is unknown if this medicine is excreted in breast milk. If you are or will be breast-feeding while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby.
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Possible Side Effects |
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In adults, the most common side effects of topamax are tiredness, dizziness, coordination problems, speech problems, changes in vision or double vision, difficulty with memory, and sensory distortion. In children, the most common side effects are drowsiness, tiredness, loss of appetite, nervousness, difficulty with concentration/attention, weight decrease, aggressive reaction and difficulty with memory. Since topamax was approved, there have been 23 cases reported (as of 8-17-01) of a sudden onset of vision and eye problems. Symptoms have typically occurred within the first month of therapy, with patients reporting an acute onset of decreased vision and/or eye pain. Eye examination revealed myopia (nearsightedness), redness, decreased depth of the anterior chamber of the eye and elevated ocular pressure, with or without dilation of the pupils. Fluid accumulation within the eye may displace the lens and iris anteriorly causing secondary angle closure glaucoma. If patients develop this syndrome, the treatment is to discontinue topamax as rapidly as possible, according to the judgment of the treating physician.
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More Information |
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Laboratory and or medical tests (e.g., eye exams) may be performed to monitor your progress. Dc with others for whom it was not prescribed. Do not use this medicine for other health conditions. Keep this medicine out of the reach of children. If using this medicine for an extended period of time, obtain refills before your supply runs out.
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| Help and FAQ |
What's the difference between generic drugs and brand-name drugs?
Actually, they both differ only in price and name, all the rest is the same. Generic drugs, as well as brand-name medications, have the same dosage, effects, including side effects, risks, strength and safety. They are like true copies of brand-name medications.
What makes generic drugs cheaper?
As a rule, in order to release and patent a certain drug the manufacturer should meet a range of requirements like developing, researching, marketing and promoting of a new medication. Overall, it is time- and money-consuming procedure, which leads to price growth. Speaking about generic drugs, they are usually brought unregistered onto the market, thus the manufacturer is exempt from paying taxes. However, the lower price here doesn't yield lower effectiveness. As a rule, the manufacturers of generic drugs are known reputable pharmaceutical companies.
What credit cards do you accept?
We accept Visa, MasterCard, AmEx, Diners and JCB cards.
Do you ship Internationally?
Yes, we ship Internationally at this time.
Order delay at customs: what to do?
It may happen that your order can be delayed at customs. In this case customs officers usually ask the recipient to come to the office and permit them to open a parcel in order to examine it. After this they give a parcel to the recipient. If you still have problems with getting your order, contact us so that we can help you solve this problem.
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